Are you sure your O1 is a single-entry? I have an O1 as well, for about 2 years now, and I have traveled out and in multiple times. Did you get the individual-associated O1 or one sponsored in the name of the employer (your startup)?

Edit: just noticed @seanmccann's comment. Dang that sucks. Apply for your EB1 asap! Under the O1, the requirements are pretty colinear, and you can skip the nationality queue that has an 8 year backlog for Chinese citizens on the EB2/3/etc.