For example, the Rembrandt Research Project infamously set out to identify genuine vs. fake Rembrandt paintings in his corpus of known works under the false assumption that there would be a lot of 18th/19th/20th century forgeries. In fact, most of the "non-Rembrandt" cases they found were not later imitations, but instead works done by his own students or contemporaries - or works co-produced by Rembrandt and another. The result - deconstructing the project's original false assumption - proved revolutionary for our understanding of artistic studio practice from the period, but failed to locate many "forgeries" as such.
A review (paywalled, sorry!): http://www.sciencedirect.com/science/article/pii/02604779899...
And a Met exhibition: http://www.metmuseum.org/art/metpublications/Rembrandt_Not_R...