However, "natural" is a reasonable heuristic for "something our bodies have had time to adapt for" and the introduction of synthetics has short-circuited the evolutionary feedback loop.
Heavy metals are probably a good example of this, perhaps in another million years there will be humans and animals that have excretive pathways for mercury.
My issue is that most of us live in a world of plenty and we do not need to incur many of the risks that we do through chemical exposure, especially as their use is typically to serve a business' needs rather than our own. Additionally, the opacity of the problem is also an issue because it is hard to make informed decisions about what we consume due to us being many levels detatched from the supply chain which produces that which we eat.