> Who knows where it'll go, but homo sapiens isn't equipped to be space-faring or even survive on this planet beyond a few billion years.
So? I don't see how that's an argument for human genetic engineering. If we want to perpetuate life throughout the universe for some reason, we can send probes loaded with microbes, maybe even advanced probes that can incubate more advanced animal and plant species to create an ecosystem. In your scenario, humanity is presented with its extinction through either natural causes or by being the architect of its own destruction. I'd prefer the former.
* Made entire species extinct through hunting and deforestation
* As a side effect of industrialization, dumped enough CO2 to change the climate and will probably keep it up
* Domesticated multiple other species into being dependent on us, from crops to farm animals to dogs
* Started work on AI and machines which might even replace us one day
Genetic modification isn't a one-way street to destruction as much as AI is, or industrialization.
Also regarding perpetuating life: the one thing life has in common is that it perpetuates itself. We'd be a shitty species if we perpetuated machines or microbes instead of ourselves.
When I visited hawaii, I noticed that there were large trees all growing on one of the oldest islands. Due to erosion, the island will eventually submerge back into the sea, and all those tress will be dead. Those trees don't know it, but their time will be up soon.
I don't know what the future holds, but shying away from technological development means that we as a species are like the trees. At least venturing to other planets would be like if the trees could send seeds across the ocean.
As far as escaping the heat death of the universe, who knows.