This second video is of particular interest to me, as it tackles a problem I've been thinking quite a lot lately : is self-modification compatible with volition? What's the point of wanting something if you can chose what to want? The pill that makes you love the idea of killing your kids is an extreme example, and probably no-one would accept to take this pill, but it's really not so obvious why. Or at least, the reasons are pretty deep.

BTW IMHO a simpler example would be a meta-suicide pill : instead of being a poison that would just kill you, it's a pill that would make you want to kill yourself. I suppose you can make people want to kill themselves by inflicting them an awful chronic pain such that death would look like the only solution, but the pill I'm thinking about would not do that : it would change your mind so that you would want to die just because you like the idea of dying, for no particular reason.