It's easy after-the-fact to see that, but it's hard to know when it's happening. Possibly the most celebrated entrepreneur is Elon Musk, and I don't think there's any question he put his company before his personal life multiple times in order to succeed. But how many other people have done that and then failed? It can leave you as a shell of your former self.
Everybody talks about the upside. Nobody wants to talk about the downside.