Depends on what you do. If you're yet another web dev who does little more than glue together other people's code, maybe. If you have a deeper skill set I think you'll be fine.
What kind of skill set are you referencing?
Robotics/instrument control, manufacturing automation, AI, image processing, computer vision, systems level stuff, large scale network/system engineering, whatever. Fields where you're solving hard problems that haven't been solved a million times already.
How does one bootstrap/find companies in this domain?