Hi,
Stanka from 0patch here. If you want to enable or disable (aka "patch" or "unpatch" the application) you don't need do restart the application. Not even if your app is running and you've just install 0patch agent. This is how it is designed to work in user space. When the official MS patch is installed (hopefully with the fix) this particular 0patch won't apply anymore.
As we try to make 0patch agent robust and reliable we don't support kernel mode at this moment - we will make this step slow and with great caution.