Nice to hear you have an audio interface working there! Sounds like you do professional audio -- curious what kind of bandwidth needs you're expecting to have?
It's a minor nit, but one reason I prefer Thunderbolt hubs is because they hang directly off the PCI bus.
Historically speaking, with USB the host CPU intermediates all bus traffic. The 'fire' in FireWire (vs e.g. USB2) was how devices could access host memory directly.
It's probably a negligible amount of overhead these days, but my take is, if it's possible to use Thunderbolt and free up CPU cycles for whatever you're doing, why not?
Love to hear opinions from someone who has more recent knowledge on this.