Aside from the small detail of the monitor getting blown away by a router nearby - a router nearby is not exactly an uncommon occurrence in a computing environment. Not to mention the other issues like possible kernel reboots and flickering caused by unknown factors.
It's a minor nit, but one reason I prefer Thunderbolt hubs is because they hang directly off the PCI bus.
Historically speaking, with USB the host CPU intermediates all bus traffic. The 'fire' in FireWire (vs e.g. USB2) was how devices could access host memory directly.
It's probably a negligible amount of overhead these days, but my take is, if it's possible to use Thunderbolt and free up CPU cycles for whatever you're doing, why not?
Love to hear opinions from someone who has more recent knowledge on this.
I do a lot of audio work for video and composition through Logic using lots of plugins and bits and it just handles it nicely. That's really all I'm bothered about ;)