There are lots of things you don't want to cut on a laser cutter unless you're cutting under an inert gas, or at least nitrogen. Polycarbonate, any of the chlorinated plastics (PVC, some synthetic leather), styrenes, and polyethylene, for example. ABS melts, and Fiberglas's glass component won't cut. Acrylics cut very well. Delrin cuts OK. Wood and cloth are OK. Techshop is careful to teach people about this.
TechShop's laser cutters have compressed air coming in, a big exhaust hose going out, and a fire extinguisher nearby. TechShop has an ad slogan, "Don't try this at home. Do it at TechShop". There's something to be said for that when you're using industrial-strength tools.
In addition to the two people, their two cats died. Operating these things in a closed room is a really bad idea.