80.80.80.80 seems to be served out of a single datacenter. Based on ping times I'm seeing, it looks like they are hosted in Amsterdam. So it will be slow for most of Asia and the Americas.
Any CDNs that are using geo-dns will be way slower than they should be outside the US as you'll have been given a US IP to load the content from.
These are, after all, just giving a more human understandable way of proving addressing information. On Unix and Unix-like systems there is a resolver, and I would be fascinated to know how hard it would be to literally swap out or choose an entirely new name-to-IP address resolution mechanism at runtime.
From multiple test locations I am seeing lots of network tromboning. Queries from the US going to Europe and vice versa.
80.80.80.80 is always 12ms. Appears to be in Amsterdam.
8.8.8.8 is between 13-60ms, usually 12-25ms. Somewhere in Sweden.