> Heart experts said at-risk patients should be helped to manage stress.

Is there any high-quality evidence that "stress management" interventions actually lead to a medically significant reduction in biological stress? I see this sort of thing mentioned in passing in lots of places as a potential mitigation, but studies that actually examine its effectiveness seem to be in short supply, and what I can dig up quickly seems to be low-quality (underpowered, not randomized, not controlled).