One thing that I've run into when running Adobe stuff on OS X is that it fails catastrophically on a case-sensitive filesystem. That would be the first thing to sort out; short of that I think it would be a matter of platform integration for color management, and windowing system integration (iBus, libnotify). I'm sure there's plenty more in the way of technical difficulties in porting Creative Cloud. One reason they might do it is to capture the film industry, which seems to do grading and compositing on Linux (which is why Autodesk's products in those categories support it).