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Dunno really. I've never used any of the technologies mentioned and things seem to have held together OK.

You can use this fork of react-scripts which adds configuration for enabling new options, including use of style preprocessors:

The irony of forking create-react-app to add configuration.

This was the killer for create-react-app for me. I resentfully ejected so I could use SASS.

I compile the Sass files separately (using Node-Sass) and require the generated CSS file.

Not at the moment.