1) Flicker: does the LED's high-speed flicker play a role in damage to the eye? (Here's an LED viewed in slow motion: https://www.youtube.com/watch?v=3wdljou1M8Q)
2) Spectrum: LEDs can have very uneven spectrums with spikes at particular frequencies (particularly in applications like street lamps that don't use phosphors). This is something an eye in nature would never experience.
Here's a great video showing LEDs strobing compared to other bulb types: https://youtu.be/1IDf16R_eJ0?t=13s