I like depersonalization. Used to get it relatively often as a kid and teen, sadly very rarely now. Guess I'm going to buy a vr!
It's like playing a rpg with 'your' body as an avatar. Which means there's (almost) nothing left except pure will. Very useful, can be used to make a character do things it wouldn't normally do and/or become much more efficient. Everything seems inherently pointless, may as well go with inertia of old goals.
That's how I imagine the first transhumans to think, only with more than one body and hopefully truly independent (ie. mind uploading, distributed computing or something similar).