Might as well treat your zpool like it's on real hardware and configure raidz accordingly. The cloud does have real, problematic hardware behind it, and it's important to remember that.
[edit] especially if you can configure your block devices such that you know they're sitting on different physical hardware at the cloud data center, you will gain that benefit of ZFS
I guess it's possible that some type of disk command timing could cause unexpected lockups or slowdowns that you wouldn't get with a system that doesn't try to control the hardware to quite the same extent as ZFS, but my (cursory) understanding is that it's rare/hardware specific.
My personal take is that running ZFS on hardware that lies is no worse than running EXT4 on it. YMMV as I'm not a storage expert.
Or in the case if EBS - NFS and a network stack. EBS is "Emulated Block Storage" despite what AWS may like you to think.