So... for instance an MD with MOOC-type machine learning could make it in health related enterprises? Is that what you mean by domain specific expertise?
Would an English MA or PhD, for example couple well with an ML-MOOC for natural language processing jobs? Possibly, but would involve a lot of effort to build the bridge. However, if someone has a mechanical engineering degree or a PhD in something similar, a MOOC-ML can work well to position them for a bunch of jobs in large mechanical engineering companies looking to jump on the ML bandwagon or ones traditionally strong in ML-type mechanical engineering like UTC.