1) That you have to trade your health. I wonder if lawyers at Biglaw live longer than the bottom 75% of income earners. My opinion is that they very likely do.
2) Smart isn't applicable to the context you set up. It's dependent on what you want out of life, these are personal life choices. If I prioritize money over life expectancy, and I get rich but die at 63 years of age (due to the work lifestyle I undertook to get rich), that was my subjective choice - smart doesn't enter into it.
3) Most people with careers trade their youth for work to some substantial degree. The exceptions are extremely few, and extremely far between. Just working 35 to 60 hours per week, from the age of 20 to 67 (the soon to be social security retirement age), is heavily trading your youth for work.