But synths and sequencers? They're not "modern". I find it hard to imagine music much more primitive than the boring wub-wub-wub of dubstep or the endless 4/4 oontz of Eurodance.
Serialization and 12-tone, for all their shortcomings, represented serious questioning of how notes should be organized at all. I think they failed because they dehumanized, and humanity is at the heart of music. A conscious disregard for consonance/dissonance isn't the same as choosing the balance of consonance/dissonance. They were interesting intellectual exercises, but as a musician, I think they deserved to die. They're the music of the past now.
Most of the real experimentalism in music I hear these days (and I have some bias here) is in the noise and free improvisation fields. I'm biased because I also play free improvisation. But undermining rhythm and harmony, and focusing on tonal evolution - that's interesting and daring. And that music is done with some seriously analog approach, not computers. Computers are generally very restrictive (although there are exceptions - the people doing million-note sequences are fascinating noise experimenters). One of the best modern music performances I've ever heard was an improvisation of one percussionist, who spent several minutes carefully wadding a piece of cellophane. It was complex, dynamic, exciting, and above all, musical - but it worked by tossing aside virtually every musical convention except "be interesting".