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I'm not the person you replied to, but I was on 350 mg (which is a reasonably high dose). I was on venlafaxine regular release, not the extended release. If I missed a dose I got full on discontinuation effects. When I tapered off it wasn't great, but it wasn't awful.

Some people do report problems even with a very gentle long taper down.

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My wife has been on venlafaxine for years, and has been tappering off it for the past year. She has had horrible withdrawl symptoms from missing a single dose, like you describe. Each time the doses town (tapering), she has a rough few weeks.

How long were you on it? Do you have any advice? Thanks.

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