This comment breaks the HN guidelines, which ask you not to complain about downvotes or bait other users into downvoting.

We detached this subthread from https://news.ycombinator.com/item?id=13213204 and marked it off-topic.

I upvoted both your comments, as I do believe they contribute to the discussion.

But I do have a question to ask you: When do you feel that statistical significance shouldn't matter? And in what context?

Lets say 171 billion people get a life saving drug, but 700 die. There I can agree with you.

171 billion people get coffee, and 700 are maimed. I think that maybe you should pay their medical bills. And maybe throw a few extra bucks in for good measure. 171 billion people generated a lot of profit. Losing $1.4 billion is not a bad deal