IIRC Windows XP 64-bit was supposed to be a pure 64-bit OS - no compatibility layer for 32-bit apps. Which is most of the reason it didn't get some great adoption.
Later versions of 64-bit Windows had that compatibility layer.
Later versions of 64-bit Windows had that compatibility layer.
https://en.wikipedia.org/wiki/Windows_XP_editions#64-bit_edi...
I think the only thing I had trouble with on that machine was finding drivers for a particular printer.