[Yes, really] [No]"
With the latter option being focused by default and emphasized?
Yes, doing that is tricky deployment-wise with open protocols, but isn't the whole point of solutions like Exchange to enable system-wide shortcuts like that?
With an open solution the next best option is probably to have the mail server send a confirmation request email back to the user with a link to click if they really wanted to send it, instructions on how to reply with a confirmation etc.