Of course not. The idea that Trump's election would be detrimental to Silicon Valley was a fear mongering tactic promulgated by left-leaning tech luminaries. Say what you will about his other stances, but all signs point to a very pro-business administration.
I'm more worried about business interruptions coming as a result of the holy war that some ultra-liberals have unleashed on anyone that they view as responsible for not getting their way in the election than I am about Trump interfering with any aspect of American business. The Grubhub incident was truly disturbing, and several people have publicly said they would cut Peter Thiel out of deals specifically because of his political beliefs. It seems that Democrats stress tolerance, except when they have to tolerate anyone that disagrees with them.