I am interested as to why you chose to focus on reaction prediction. As you acknowledge in the introduction, the acquistion of this skill is a routine part of graduate education in synthetic chemistry.

On the other hand, the key difficulty in synthetic chemistry, and the one that occupies the majority of a chemist's time is the identification of the correct reagent(s), the correct solvent, and the correct time, temperature, and concentration such that the desired reaction proceeds in a convenient amount of time and with the correct chemo- and regio-selectivity, that the reaction conditions are tolerated by the rest of the molecule, and that the product can be easily isolated from the reaction byproducts.

In my opinion, as long as these problems remain, then being able to turn retrosynthetic analysis over to a machine appears to me to provide little benefit.