https://www.gwern.net/Nicotine is interesting reading.
Of course, e-cigarette liquid is not only nicotine, so who knows what the long term effect of that is. The chromium in the heating coils worries me personally. (Kanthal and stainless steel both contain chromium. Obviously stainless steel is designed to be relatively inert, so maybe it's OK. Titanium is another option, and is implanted in the body regularly. But things are different at high temperatures.)
(I actually used Kanthal wire sold for DIY vaping things professionally at one point, in a ~1200C heater in vacuum. It's not inert enough in those conditions, sadly)
Stainless steel coils facilitate temperature-controlled vaporisation, which is a crucial advance in harm reduction. Controlling the temperature of vaporisation significantly reduces the production of aldehydes and aromatic hydrocarbons, which are created by the thermal decomposition of propylene glycol and glycerine; these decomposition products are by far the most dangerous components of e-cigarette vapour.
http://www.ecigarette-research.org/research/index.php/resear... http://onlinelibrary.wiley.com/doi/10.1111/add.12942/abstrac...
Stainless or Kanthal at 500C or something should indeed be quite inert, it's just not that hot.
Power-controlled devices rarely exceed 300C in normal use, because there is considerable airflow over the coil combined with evaporative cooling. Excessive temperatures can be reached if the device is inadvertently activated, or if the liquid flow to the coil is inadequate.
As you say, kanthal and stainless steel should be very stable at these temperatures. Pure titanium wire also works with temperature control and completely avoids the issue of chromium, but there is some debate over the potential risks of titanium dioxide nanoparticles.
More than that, you'll know immediately it's happened because it tastes awful.
Same thing with formaldehyde - nobody is ever going to willingly inhale it, since its presence means your vape is going to taste awful.
http://dailycaller.com/2016/03/05/formaldehyde-fears-used-to...
Agreed, it's tobacco that is the primary issue.
I've been curious to adopt the e-cig for the stimulant aspect. I likely won't, but will admit to being curious if it would be a productivity boost. I'd bet the e-cig companies could gain a whole new market if they published some quasi-scientific material on the productivity benefits of nicotine.
Did you read the instructions? You're supposed to chew on it for a bit, than 'park' the gum between your gum and teeth, let it sit for a minute or two, rinse, repeat. If you chew continuously you get the whole dose quickly, which can be a bit unpleasant if you don't like the nicotine buzz.
That's a big part of the cigarettes many persons (anecdota) have trouble with quitting outside of the addictive properties: the learned habits.
I think the idea is that when vaping, you are able adjust the level of nicotine you are consuming without having to adjust how often you engage in the physical act of vaping/smoking. The act is a comfortable ritual, a chance to take a break, step away, relax for a few moments, whatever. It's a habit itself, distinct from the nicotine dependency. Quitting smoking is doubly painful if you are craving both the chemical and the act. Vaping gives you the act without the chemical.
This doesn't even touch the fact that nicotine is not particularly harmful - simply a habit-forming stimulant like caffeine, adderall or modafinil. Vaping delivers the nicotine without the tar, and the tar is what kills. The thing that makes people nervous about vaping is not the nicotine, but the behavior of the (largely unstudied and unregulated) substances in the vapor being inhaled.
A cigarette has become a somewhat expensive object. When I light it up I would finish it, or at least try to. If the time I had for my smoke break was short I would puff that thing hard to get it done in the time I had allotted. An e-cig can be used for a few puffs and then dropped back into my pocket with nothing wasted. I could be much lazier about how I smoked and as a consequence I tended to smoke less.
Vaping just didn't fill that void and I think that's part of the reason I gave up (the other being that I just couldn't find a flavour I actually liked, no matter how close the name of it is to 'golden virginia', it never tasted remotely as close)
I'm creeped out by whatever's in e-cigs. I'm don't know why everyone is so sure that constantly inhaling propylene glycol for years on end is safe, or that all that's in that mystery imported off-brand liquid is propylene glycol. I of course find it extremely likely that it's less unhealthy than smoking.
I quit through using Swedish snus. I think it was crucial that snus isn't fun, and gives you nothing to do with your hands. To gradually wean off nicotene, just leave the portions in longer. Twenty-year smoker, two-year snuser, four years tobacco-free.