You can of course use one of many existing templates, but you will quickly feel lost when you have to customize things.
These days, just go with Markdown (or the like) and just include assets (say graphs) as SVG and be done with it.
For scientific papers (especially with two columns layout) you probably have to go with LaTeX though.
Edit: By the way, my take at minimal LaTeX templates: https://github.com/renke/latex-templates