I have the CAPS LOCK mapped to the escape key, which is great for Vim, etc. However, there's one weird edge case problem. In After Effects the CAPS LOCK is the one quick way to speed up rending of animations, by disabling the render to screen option. It's oddly hard coded to that key specifically and seems difficult to remap to anything else. I know I probably represent 1 of 10 people world-wide who have this problem, but I'm sure there are other odd things hard mapped to the sad ol' CAPS LOCK key.