Varnish is a lot easier to configure if you have some complexity, for example if you want to cache the same page but for different languages that is sent from the browser.
There is also another alternative, Apache Traffic Server.
In the end, it may be Nginx, Apache Traffic Server which are the right tools for your problem. None of them solves every caching problem.
It seems kind of nasty to say this, but nginx isn't the be all and end all. Now, yeah, you could say I'm biased, but this is because instead of being swayed by marketing, PR and FUD, I instead am swayed by real world scenarios. nginx is very, very good, but it is no longer heads-and-shoulders above httpd or anything else really. It is weird, and wrong, to take every other tool which does a part of what nginx does and immediately want to criticize it or say "nginx does that too! What do we need Foo for?!" When doing architecture, pick the right tools for the right job. And most of the time that means picking a caching layer, a TLS termination layer, dynamic content, Authn&Authz layer, etc...
Up to a certain high load, Varnish works well, then all hell breaks loose - Nginx in comparison was much more stable and used less resources, had a higher max throughput, and when it hit the max - (assuming it filenode limit was high enough) would still work..just slowly. Varnish just died.
I encourage people to read http://capriccio.cs.berkeley.edu/pubs/threads-hotos-2003.pdf. Yeah, it's old, but so is the 10k Concurrency paper which is still touted as the reason why people should use nginx instead of anything else. Threads will only get better.
http://stackoverflow.com/questions/16693677/why-isnt-varnish...
If you really need a large malloc, I highly recommend running Varnish on FreeBSD instead of Linux as the Linux kernels VM system is horrible when memory is overcommitted.