Are there special optimizations implemented for different use cases as well, e.g. screen v. print and sub-varieties of each? Ten years ago with Vista, Microsoft Typography (https://www.microsoft.com/en-us/Typography/default.aspx) put out a family of typefaces--Cambria, Calibri, Consolas, etc.--which were optimized specifically for sub-pixel rendering on LCD screens while maintaining on-paper legibility. I'd be cool with Noto not having any such optimization in mind given that the stated objective appears to be to include every defined character, but I do wonder if it should happen eventually.
...or maybe not, who knows. Pixel densities now have approached ludicrous territories. It might just no longer matter at least when we're talking about optimizing for screens.