I never tried uMatrix. uBlock has the ability to block a particular set of links e.g. abc.com/min/* and whitelist some links within that set e.g. abc.com/min//.png. I think that's a fine grain approach. Can uMatrix do things like this?
Here is a quick tutorial showing what uMatrix can do https://github.com/gorhill/uMatrix/wiki/Very-bare-walkthroug.... As you can see, it gives you an easier way to have fine-grained control of each individual type of resource. It also allows you to configure third-party domain resources globally, or per domain. This allows you to do something like allow youtube embedding (js + xhr) on all websites at once.