Road direction can be ambiguous. Fairly obvious with a loop like I-270 around Columbus, Ohio. I've thought they should have designated the direction as clockwise and counterclockwise, going around the loop for a significant portion gets confusing re: "North" which may be actually east or west.

Also I-84 in western Idaho is more north-south even though it's even-numbered and nominally and east-west highway. Probably not too confusing because roads are much more sparse in that part of the country, people navigate on the basis of destinations, the exact direction is kind of hypothetical.

No surprises in it though, real-world roads won't follow the abstract grid very closely, there are going to be quite a few exceptions.