(Like maybe rotate one of these North-South roads to run East-West.)
(Like maybe rotate one of these North-South roads to run East-West.)
Also I-84 in western Idaho is more north-south even though it's even-numbered and nominally and east-west highway. Probably not too confusing because roads are much more sparse in that part of the country, people navigate on the basis of destinations, the exact direction is kind of hypothetical.
No surprises in it though, real-world roads won't follow the abstract grid very closely, there are going to be quite a few exceptions.
Further aside, given the the similarity in numbers of I-264 and I-265 they are more commonly referred to by their expressway names, the Watterson and the (Gene) Snyder, respectively. Louisville is one of the few cities I know of where you'll meet natives that don't actually know the interstate numbers they drive on sometimes every day, you have to mention it by name to get the right directions.