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A lot of the meta around NT has to do with knowing what weapons work well across stages of the game and are complementary, then balancing ammo requirements with the need to dish out spike damage.

If you haven't made it past the sewer that you've probably seen < 15% of the game. I've particularly found melee weapons(wrench) particularly good at dealing with the sewers.

Catacomb Kids might suit you. It has a lot of depth of interaction.

Thanks! I hadn't seen that one yet.

I haven't played it yet (waiting for the full release), but this video about the many, many uses for a small rock sold me on backing Catacomb Kids: https://www.youtube.com/watch?v=N59tLIvQeJE

Have you played Spelunky, the very first roguelikelike? It can be surprisingly deep.