Additionally, there is a transformation that takes place in our brains from information to knowledge. Our understanding of this process is also pretty weak.
Both of these problems are fundamental to the creation of true, autonomous AI.
I don't agree that this is true in any way that precludes the creation of "true, autonomous AI". We may not understand the specific mechanisms of how our brains give rise to creativity and the resulting "implementation artifacts", but the fundamental part of creativity (and I'd argue, the part that's relevant to AI) is the ability to efficiently search huge but structured hypothesis spaces and inductively learn new structure (very likely with some stochastic element involved).
That is something that we not only have an understanding of, but have implemented, more than once. By way of examples:
http://www.popsci.com/scitech/article/2006-04/john-koza-has-... http://aliciapatterson.org/stories/eurisko-computer-mind-its... https://psmag.com/triumph-of-the-cyborg-composer-620e5aead47...
What makes you say that? I could see your statement being self-evidently true only if you meant "fundamental to the creation of an anthropomorphized AI." Of course, even that glosses over the fact that there are already strong indications within the AI community that the first general purpose AI will likely not "think" even remotely in the same fashion as humans do.