I once bought a fake charger and you could feel a tinkly sensation around the mousepad while it was charging. Obviously I threw it out quickly.
I recently experienced this while travelling to India. Turns out the house I was staying at had a grounding issue and I couldn't do anything. This is less likely for most people and it's just better to use the cable with the grounding pin.
Both chargers where connected without ground using the 2-prong round adaptor.