I don't know you, and I wouldn't presume to know anything about you other than what you've revealed in your comments, but what I can say is that you've been handed enough lego blocks to build anything you want to, and it seems like you've set them aside because they're not the specific blocks that you had in mind to build the thing that you envisioned at some point in the past.
No one automatically receives happiness. But you have an obligation to work on yourself, to do better than you seem to be doing, at building a happy self out of the life that you've made. That obligation is a result of choices you've made to build a family. Like it or not, you owe it to your wife and children to do the extra work of finding the meaning and sense of significance that is absolutely there waiting to be uncovered by you, and put to use by you.
All of the extrinsic life experiences you've mentioned in your comments do not entitle you to wait for something to click, to be more than a 'yawning void of nothing'.
If what you're talking about is something that you face no matter how many good, wise, smart moves that you make, then you may need to face the reality that you need treatment for depression or some other issue.
No amount of travel or physical trials that you've put yourself through can supplant the reality that you can build for yourself by simply looking inward. In fact, it seems as though by constantly abstracting the search into various physical or worldly concerns, you've done the opposite.
Happiness and fulfillment are moving targets. Personally, I suspect that I may never get all the way there. But I've spent some time on the road you're describing, and I know it's a dead end road. It's ego, it's self-indulgence, it's blame, it's a withering loneliness that makes you a small island, one that can be described in just a few seconds with cliches, easily traversed by foot, and forgotten or ignored by others.
Whether or not you're clinically depressed, you should probably work on the quality of your relationships. Are there people that you can authentically connect with? If not, find them. They're out there. Are there people with whom your connection leaves you feeling bad or more isolated? Get rid of them. Are there people that you keep trying to connect with but it doesn't happen? Stop trying, and refocus your energy on authentic connections. Are there superficial connections that satisfy some social or validating urge that you have? Figure out whether your relationships with those people can be evolved into authentic, meaningful connections or not, and work on the good ones and discard the bad ones.
It's an absolute tragedy to waste all of the time and beautiful experiences and memories that you could be accumulating with all of the people in your life, for lack of addressing a few relatively simple and totally fixable issues.