IIRC lists and tuples are implemented nearly identically in CPython. So you won't find much difference here.

Because Python is so dynamic, you can't make lists or tuples much better. However, in a static language (like Java or OCaml), you can greatly shrink the size of "cultural" lists by hoisting the (identical) run-time type info out of the elements and into the container. (OCaml does this with floats.) And "cultural" tuples typically can use much simpler implementations, since their sizes are fixed and known at compile time. (C structs are often optimized away entirely in optimized assembly.)