(HAProxy + Mongrel) and (Apache/Nginx + Passenger) work great. Don't get me wrong, I've seen lots of different Rails server architectures and I've spoken at RailsConf on this very topic. I would recommend either setup to a Rails startup in an instant.
But in the edge case of immense load, they simply don't keep up to Unicorn.
The thing that sets Unicorn apart is that it does it's load balancing on the Kernel level. All Unicorn worker processes are listening on the same socket. The OS takes care of getting each request to a single, available worker. So unlike Mongrel, you don't end up with per-worker queues. Though HAProxy is smart about distributing load well, Unicorn makes it seamless. The workers simply ask for a new request and the Kernel gives it one.
There are some other niceties too. Unicorn processes are forked from a master process. If you are using REE, they can keep Rails in a shared memory. When we deployed it, we dropped memory usage by 30%.
On top of all that, Unicorn's flawless rolling restarts are a pretty big plus.
In conclusion, if you're in the top 10% of Rails apps by traffic, give Unicorn a look. It is likely that switching over is worth the dev risk and cost. Otherwise, keep it on your radar, but don't consider it a must-have.
[reference]
http://unicorn.bogomips.org/DESIGN.html
http://news.ycombinator.com/item?id=872283