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No modifier keys necessary for the directional arrows, if you mean the ones that move the cursor? They're under your pointer and middle finger on each side. Having return key (and backspace, space, and mod keys) always directly under your strongest fingers ends up feeling really natural and efficient, in my experience.

I was talking about the https://shop.keyboard.io thingy.

The firmware is open source and you should be able to remap the tab, return and any other key you'd like anywhere you please.

My experience with remapping my mind to the Advantage2 keyboard was that it took a week to be reasonably usable, and a month before I was back to my normal flow. All wrist pain gone. It is really nice to have many of your most used keys on your thumbs instead of your pinkies.

All keys are remap-able. I have moved the arrows to the left.

And yes it takes time getting used to. I am faster on regular keyboards.

But with this one I don't have pain.