Isn't that basically happened to IBM when they emulated Windows in OS/2? Devs didn't bother to build anything for OS/2.
There were many other factors that killed OS/2. Just before Warp was released, it was quite hyped in the press. The then unreleased Windows 95 was considered to be a train wreck and OS/2 a true 32-bit operating system. However, once people got their hands on Warp, it turned out that the installation was difficult unless you had hardware that was covered by the relatively small driver base. Moreover IBM didn't really seem to care about supporting OS/2 for end users. So, much of the enthusiasm evaporated even before Windows 95 was released.