I use Firefox about 80% of the time. I use Chrome for a few sites I need for work that still use Flash.
I really don't notice this performance issue. I don't use Slack, but do use Google Maps, Google Drive/Docs/Sheets and Gmail and it's all just fine in Firefox from my perspective.
I tend to not keep large numbers of tabs open (just habit more than anything) so that may be part of it. E.g. 10 tabs would be a lot for me.
I also don't sync settings. In fact I have no settings: I have firefox set to basically dump everything (cache, history) upon exit.