As a personal anecdote, my website has been blacklisted multiple times by safebrowsing, downloads have been blocked as "XXX is malicious", multiple AV products have found "malware" in a program that's never even been released before, etc. I have to email 10-20 different anti-virus companies with samples every release and then deal with the ones who want it in a different format or submitted through a web portal instead.
Then we have the problem that contacting any human about safebrowsing false positives is nigh impossible. Take a look at the report right now - https://www.google.com/transparencyreport/safebrowsing/diagn... - "Some pages on this website send visitors to dangerous websites. Some pages on this website install malware on visitors' computers." yet it says "Current status: Not dangerous". And Webmaster tools can't seem to find anything specific: http://i.imgur.com/HzT8xfC.png