If you're coming from a MATLAB background, you might find this helpful [0].

When I switched from MATLAB to Python/numpy/scipy, I had to deal with these syntactic annoyances. But now I feel comfortable after using it for many years.

Don't forget the biggest edge Python has over MATLAB for numeric simulation, i.e., you can prototype your work as quickly, and for the same program, convert the slow portions into C or Fortran without the need to rewrite the whole thing. Not to mention, a proper programming language underlying the numeric system.

[0] https://docs.scipy.org/doc/numpy-dev/user/numpy-for-matlab-u...