I guess to each their own.

I never found the clubbing in SF to come close to any of the places in Asia (Tokyo, Shanghai, Kuala Lumpur, Singapore, Taipei). Similarly for bars Japan, at least for me, have SF beat by a long shot. You have your choice of quiet bars. Bars with 5 people. Bars for every type of drink. Themed bars. In SF all I found was extremely loud and crowded bars. Maybe it was just the bars my friend chose in SF the 7 years I lived there.

SF has tons of crime. Walk down any street in SOMA or the Mission and you'll see piles of glass from all the cars that were busted into in the few nights before.

Down in the south bay you lose any of the "city" benefits as it's all just suburbia. If you like suburbia (kids/family) that's great but it wasn't for me.