PyPy 5.3.0 is twice as slow as Python 3.5.0 for some work I regularly deal with (1.1s for PyPy, 0.6s for CPython). Another project it is ~40% slower (7.7s vs 5.6s).
Additionally, PyPy just released an alpha containing compatibility with Python 3.3 (which was released four years ago). There are some nice additions to the language in 3.4 and 3.5.
Is this because you are using ctypes or a C extension written against the CPython API? If not, have you filed a bug report?
Currently I don't have an interest in taking time to try and make PyPy less slow for my use case, for many reasons that I'm not going to get into here. (But I will note I'm primarily writing code that focuses on being easy to distribute. Most users aren't going to have PyPy installed anyway.)
Anyway, the main thrust of my post is just that Python isn't a monoculture in which PyPy is always a better solution.
That said, PyPy is awesome. :-)