There's a bunch of apps that are trying to make virtual desktops in VR or 360 movies and the like. I don't personally buy into those that much, I think 360 movies are difficult to make interesting and virtual desktops are more for Augmented Reality.
Besides the obvious (VR games), I think there is a potential for a new form of entertainment (maybe a hybrid of theatre/cinema), for more advanced design tools that make faster work of 3D-based design, for educational experiences. Some things might be "replacements", but there are a lot of possibilities that a VR environment opens up for things that would not be compelling or practical on a 2D screen with common input controls.