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> hyperpermeable colon

Sounds like a fancy word for the fanciful "leaky gut syndrome".

Leaky gut is not a real diagnosis, and is mixed up with a lot of quackery and pseudoscience.

https://en.wikipedia.org/wiki/Leaky_gut_syndrome

Not sure why you were downvoted.

So-called “leaky gut syndrome” is legit, and likely plays a role in food allergies, type-1 diabetes, Celiac disease, Crohn’s disease, irritable bowel syndrome and other digestion-related maladies, Fasano says. But at the same time, he says the term “leaky gut” has for decades been “used and abused” by some alternative medicine practitioners who—without scientific evidence—cited it as the cause of everything from autism to cancer.

As a result, “the scientific community vilified the idea of leaky gut,” Fasano says. Despite the growing body of evidence, many medical practitioners are still coming to grips with the fact that leaky gut is a legitimate contributor to some ailments.

The science is constantly evolving: http://time.com/4178015/leaky-gut-syndrome-probiotics/

That's a Time article...the scientific consensus says otherwise. Also notice how he says "likely". I think that is perhaps being over optimistic.

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